Light triggering of 5-aminolevulinic acid from fused coumarin ester cages
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چکیده
منابع مشابه
Practical Considerations in the Pharmaceutical Analysis of Methyl and Hexyl Ester Derivatives of 5-Aminolevulinic Acid
Photodynamic therapy (PDT) using topical 5-aminolevulinic acid (ALA), a water-soluble precursor of the potent endogenous photosensitiser, protoporphyrin IX (PpIX), is a treatment and diagnostic tool for premalignant and malignant skin cancers. However, to improve drug delivery to deeper skin lesions, more lipophilic ALA esters have been investigated. Owing to the necessity in drug delivery rese...
متن کاملWhite-light toxicity, resulting from systemically administered 5-aminolevulinic acid, under normal operating conditions.
This study has investigated damage to the intraperitoneal organs of the rat after systemic (intraperitoneal and intravenous) administration of low doses of 5-aminolevulinic acid (ALA) and illumination with a standard white-light operating-room (o.r.) lamp. The study has been done within the framework of a larger study in which the possibility of using ALA for localization of small-volume macros...
متن کاملChemically triggered release of 5-aminolevulinic acid from liposomes.
5-Aminolevulinic acid (5-ALA), a prodrug of Protoporphyrin IX (PpIX), is used for photodynamic therapy of several medical conditions, and as an adjunct for fluorescence guided surgery. The clinical problem of patient photosensitivity after systemic administration could likely be ameliorated if the 5-ALA was delivered more selectivity to the treatment site. Liposomal formulations are inherently ...
متن کامل5-aminolevulinic acid from photosynthetic bacteria and its applications
Tangprasittipap, A. and Prasertsan, P. 5-aminolevulinic acid from photosynthetic bacteria and its applications Songklanakarin J. Sci. Technol., 2002, 24(4) : 717-725 This paper gives an overview on ALA production by photosynthetic bacteria concerning biosynthesis and regulation as well as its application as herbicide, insecticide and growth stimulator. Recent medical applications in the field o...
متن کاملEngineering Corynebacterium glutamicum to produce 5-aminolevulinic acid from glucose
BACKGROUND Corynebacterium glutamicum is generally regarded as a safe microorganism and is used to produce many biochemicals, including L-glutamate. 5-Aminolevulinic acid (ALA) is an L-glutamate derived non-protein amino acid, and is widely applied in fields such as medicine and agriculture. RESULTS The products of the gltX, hemA, and hemL genes participate in the synthesis of ALA from L-glut...
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ژورنال
عنوان ژورنال: New Journal of Chemistry
سال: 2017
ISSN: 1144-0546,1369-9261
DOI: 10.1039/c6nj03787a